市場 正良 (Masayoshi Ichiba) MD, PhD

市場 正良 (Masayoshi Ichiba)

 昭和36年生まれ 社会医学講座教授

 

学歴

昭和61年 佐賀医科大学卒業

 

主要職歴

昭和61年 佐賀医科大学助手(地域保健科学講座)

平成4年 文部省在外研究員(カロリンスカ研究所,スウェーデン)

平成13年 佐賀医科大学助教授(地域保健科学講座)

平成15年 佐賀大学医学部助教授(社会医学講座)

平成19年 佐賀大学医学部教授(社会医学講座)

平成21年 佐賀大学環境安全衛生管理室長(兼任)

 

専門分野  

産業医学,環境医学

 

研究テーマ  

生物学的モニタリング,シックハウス

 

所属学会  

日本衛生学会,日本産業衛生学会,日本公衆衛生学会,日本環境変異原学会,日本臨床環境医学会

 

その他所属

佐賀労働局労働衛生指導医,佐賀産業保健推進センター相談員

主要論文 

Ichiba M, Tomokuni K (学位論文). Studies on erythrocyte pyrimidine 5'-nucleotidase (P5N) test and its evaluation in workers occupationally exposed to lead. International Archives of Occupational and Environmental Health 1990 62:305-310

 

Ichiba M, Tomokuni K, Mori K. Erythrocyte nucleotides in lead workers. International Archives of Occupational and Environmental Health 1992 63:419-421

 

Ichiba M, Hama H, Yukitake S, Kubota M, Kawasaki S, Tomokuni K. Urinary excretion of 3,4-dimethylhippuric acid in workers exposed to 1,2,4-trimethylbenzene. International Archives of Occupational and Environmental Health 1992 64:325-327

 

Ichiba M, Hagmar L, Rannug A, Hogstedt B, Alexandrie A-K, Carstensen U, Hemminki K. Aromatic DNA adducts, micronuclei and genetic polymorphism for CYP1A1 and GST1 in chimney sweeps. Carcinogenesis 1994 15:1347-1352

 

Ichiba M, Wang Y, Oishi H, Iyadomi M, Shono N, Tomokuni K. Smoking-related DNA adducts and genetic polymorphism for metabolic enzymes in human lymphocytes. Biomarkers 1996 1:211-214

 

Ichiba M, Wang Y, Oishi T, Zhang J, Iyadomi M, Minagawa M, Tomokuni K. Lymphocytes DNA adducts and genetic polymorphism for metabolic enzymes in low dose cigarette smokers. Biomarkers 1998 3:63-71

 

Ichiba M, Wang Y, Zhang J, Tomokuni K. Effects of genetic polymorphism for metabolic enzymes on the relationship between smoking dose and DNA adducts in lymphocytes. Biomarkers 1998 3:425-432

 

Zhang J, Ichiba M, Wang Y, Yukitake S, Tomokuni K. Relation between polymorphism of δ-aminolevulinic acid dehydratase and some parameters in lead workers. Journal of Occupational Health 1998 40:77-78

 

Wang Y, Ichiba M, Iyadomi M, Zhang J, Tomokuni K. Effects of genetic polymorphism of metabolic enzymes, nutrition, and lifestyle factors on DNA adduct formation in lymphocytes. Industrial Health 1998 36:337-346

 

Pan G, Hanaoka T, Yamano Y, Hara K, Ichiba M, Wang Y, Zhang J, Feng Y, Shujuan Z, Guan D, Gao G, Liu N, Takahashi K. A study of multiple biomarkers in coke oven workers - a cross-sectional study in China. Carcinogenesis 1998 19:1963-1968

 

Kiyohara C, Ichiba M, Zhang J, Nakanishi Y, Takayama K, Hara N, Hirohata T. Relationship between aromatic-DNA adduct levels and inducibility of the drug metabolising enzyme aryl hydrocarbon hydroxylase in lymphocytes. Medical Science Research 1999 27:651-655

 

市場正良 最近10年間における労働衛生検査精度の向上 労働衛生管理 1999 10(4):12-19

 

Zhang J, Ichiba M, Feng Y, Pan G, Hanaoka T, Yamano Y, Hara K, Takahashi K, Tomokuni K. Aromatic DNA adducts in coke oven workers in relation to exposure, lifestyle and genetic polymorphism of metabolic enzymes. International Archives of Occupational and Environmental Health 2000 73:127-135

 

Zhang J, Ichiba M, Kiyohara C, Nakanishi Y, Takayama K, Hara N, Tomokuni K. The relationship between aryl hydrocarbon hydroxylase activity and DNA adducts measured by 32P-postlabelling assay in lymphocytes of lung cancer patients. Biomarkers 2000 5:152-157

 

Ichiba M, Wang Y, Zhang J, Iyadomi M, Enoki M, Tomokuni K. Inter-individual variation of smoking related DNA adducts in lymphocytes - relationship to mRNA levels for CYP1A1 and DNA repair enzymes. Biomarkers 2000 5:235-239

 

Ichiba M, Zhang J, Kiyohara C, Nakanishi Y, Takayama K, Hara N, Enoki M, Tomokuni K. Lymphocyte DNA adducts and polymorphisms in the DNA repair enzyme XPD. Biomarkers 2001 6:289-293

 

Zhang J, Ichiba M, Hara K, Zhang S, Hanaoka T, Pan G, Yamano Y, Takahashi K, Tomokuni K. Urinary 1-hydrixypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes. Occupational and Environmental Medicine 2001 58:716-721

 

市場正良,桑名房一,戎脇まゆみ,金村茂,島田裕 尿中δ‐アミノレブリン酸10年間の分布区分推移 鉛則に係わる生物学的モニタリング分布区分 労働衛生管理 2001 12(1):30-34

 

市場正良,坂井公,山田周,他 有機則に係わる生物学的モニタリング 分布区分の経年的推移 労働衛生管理 2001 12(3):54-59

 

Lee J, Kang D, Lee K, Ichiba M, Zhang J, Tomokuni K, Hwang E, Ha M, Kim S, Han S, Choi J, Lee E, Jang J, Strickland P, Hirvonen A, Cho S. Influence of GSTM1 genotype on association between aromatic DNA adducts and urinary PAH metabolites in incineration workers. Mutation Research 2002 514:213-221

 

Zhang J, Ichiba M, Hanaoka T, Pan G, Yamano Y, Hara K, Takahashi K, Tomokuni K. Leukocyte 8-hydroxydeoxyguanosine and aromatic DNA adduct in coke-oven workers with polycyclic aromatic hydrocarbon exposure. International Archives of Occupational and Environmental Health 2003 76:499-504

 

Lee K, Ichiba M, Zhang J, Tomokuni K, Hong Y, Ha M, Kwon H, Koh S, Choi H, Lee K, Park C, Cho S, Hirvonen A, Strickland P, Vermeulen R, Hayes R, Kang D. Multiple biomarkers study in painters in a shipyard in Korea. Mutation Research 2003 540:89-98

 

Ichiba M, Matsumoto A, Kondoh T, Horita M, Tomokuni K. Decreasing urinary PAH metabolites and 7-methylguanine after smoking cessation. International Archives of Occupational and Environmental Health 2006 79:545-549

 

Sasaki T, Yoshida K, Shimura H, Ichiba M, Sasahira T, Shimomoto T, Denda A, Kuniyasu H. Inhibitory effect of linoleic acid on transformation of IEC6 intestinal cells by in vitro azoxymethane treatment. International Journal of Cancer 2006 118:593-599

 

Ichiba M, Ogawa Y, Mohri I, Kondoh T, Horita M, Matsumoto A, Yoshida R, Matsumoto Y, Saito H, Ohba K, Yamashita Z, Tomokuni K. Analysis of urinary metabolites of polycyclic aromatic hydrocarbons in incineration workers. Journal of Occupational Health 2007 49:159-164

 

市場正良, 高橋達也,山下善功,高石恵子,西村晃一,蒲池将史, 近藤敏弘,松本明子,上野大介,宮島徹. 佐賀環境フォーラムにおけるシックスクール問題への取り組み. 日本衛生学雑誌 2009 64:26-31


Yamamoto S, Natsumeda S, Hara K, Yoshida S, Sakurai H, Ichiba M.,Applicability of Concentrations Obtained by Working Environment Measurement to Assess Personal Exposure Concentrations of Chemicals,Journal of Occupational Health,56:85-92,2014


Yamano Y, Hara K, Ichiba M, Hanaoka T, PanG, Nakadate T,Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons : a cross-sectional study of coke oven workers in China,International Archives of Occupational and Environmental Health ,87:705-713,2014

 

主要著書 

市場正良 DNA付加体:32P-ポストラベル法:環境発がんのブラックボックスをさぐる -産業分子疫学のチャレンジ- 花岡知之編 労働科学研究所出版部 川崎 1999 75-104

 

市場正良 ベンゾピレン,ピレン,ナフタリン:環境化学物質の代謝とその周辺 荻野景規 小栗一太監 日本公衆衛生協会 東京 2003 1-18

 

市場正良 白血球DNA付加体を指標とした環境発がんのリスク評価 日本衛生学雑誌 2004 59:311-316


市場正良,鉛,水銀,マンガン,クロム,カドミウム,ベリリウム,ヒ素:産業保健マニュアル,南山堂,231-239,2013