松本 明子 (Akiko Matsumoto) MD, PhD

松本 明子 (Akiko Matsumoto)

1974年生まれ 社会医学講座講師

 

 

学歴

産業医科大学医学部卒(1999)

産業医学基本講座過程修了1999)

 

免許・学位

医師免許(1999)

作業環境測定士(第一種、有機、特化)(2007)

大気関係第一種公害防止管理者(2007)

医学博士号(乙)(佐賀大学)(2008)

社会医学系指導医(2017)

 

受賞

Aldh2ノックアウトマウス学会賞(2008)

日本衛生学会奨励賞(2016)

 

主要職歴

1999.6   産業医科大学病院神経内科学 産業医学修練医(臨床研修医・産業医修練コースⅡ)

2000.6   産業医科大学医学部衛生学講座助手

2002.12 佐賀大学医学部社会医学講座助手/助教

2009.10 Visiting Research Associate

                   Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus

2011.12~ 現職

 

その他職歴

2000~2009、2012~ 嘱託産業医

2001~2009、2012~ 産業保健センター相談員

2006~2009、2012~ 佐賀県環境影響評価審査会委員

2017~         佐賀県薬物検討審査会委員

     

研究テーマ  

遺伝子多型と健康影響の関係.

生物学的モニタリングと評価.

内分泌攪乱化学物質による健康影響.

 

所属学会  

日本衛生学会 日本産業衛生学会 日本内科学会 Aldh2ノックアウトマウス学会

主要論文

Isse T, Oyama T, Kitagawa K, Matsuno K, Matsumoto A, Yoshida A, Nakayama K, Nakayama K, Kawamoto T. Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics. 2002 Nov;12(8):621-6.

 

Oyama T, Kawamoto T, Matsumoto A, Isse T, Ozaki S, Yasumoto K. エビデンスに基づく予防 : チトクローム2E1遺伝子多型に基づいた肺癌予防への取り組み Evidence Based Prevention (EBP) : Evidence-Based Approach to Prevention of Lung Cancer by Application of Cytochrome 2E1 Polymorphism. J UOEH. 2002 Dec 1;24(4):413-21. 

 

Matsumoto A, Kunugita N, Kitagawa K, Isse T, Oyama T, Foureman GL, Morita M, Kawamoto T. Bisphenol A levels in human urine. Environmental Health Perspectives. 111(1): 101-104 (2003) 

 

Oyama T, Kagawa N, Kim YD, Matsumoto A, Isse T, Kawamoto T. Lung cancer andCYP1A1 orGSTM1 polymorphisms. Environ Health Prev Med. 2003 Jan;7(6):230-4.

 

Oyama T, Kawamoto T, Matsuno K, Osaki T, Matsumoto A, Isse T, Nakata S, Ozaki S, Sugaya M, Yasuda M, Yamashita T, Takenoyama M, Sugio K, Yasumoto K. A case-case study comparing the usefulness of serum trace elements (Cu, Zn and Se) and tumor markers (CEA, SCC and SLX) in non-small cell lung cancer patients. Anticancer Res. 2003 Jan-Feb;23(1B):605-12.

 

Oyama T, Matsumoto A, Isse T, Kim YD, Ozaki S, Osaki T, Sugio K, Yasumoto K, Kawamoto T. Evidence-based prevention (EBP): approach to lung cancer prevention based on cytochrome 1A1 and cytochrome 2E1 polymorphism. Anticancer Res. 2003 Mar-Apr;23(2C):1731-7. Review.

 

Kim YD, Todoroki H, Oyama T, Isse T, Matsumoto A, Yamaguchi T, Kim H, Uchiyama I, Kawamoto T. Identification of cytochrome P450 isoforms involved in 1-hydroxylation of pyrene. Environ Res. 2004 Mar;94(3):262-6.

 

Ogawa M, Isse T, Oyama T, Kunugita N, Yamaguchi T, Kinaga T, Narai R, Matsumoto A, Kim YD, Kim H, Uchiyama I, Kawamoto T. Urinary 8-hydoxydeoxyguanosine (8-OHdG) and plasma malondialdehyde (MDA) levels in Aldh2 knock-out mice under acetaldehyde exposure. Ind Health. 2006 Jan;44(1):179-83.

 

Ichiba M, Matsumoto A, Kondoh T, Horita M, Tomokuni K. Decreasing urinary PAH metabolites and7-methylguanine after smoking cessation. Int Arch Occup Environ Health.2006 Aug;79(7):545-9. 

 

Matsumoto A, Ichiba M, Horita M, Yamashita Z, Takahashi T, Isse T, Oyama T, Kawamoto T, Tomokuni K. Lack of aldehyde dehydrogenase ameliorates oxidative stress induced by single-dose ethanol administration in mouse liver. Alcohol. 2007 Feb;41(1):57-9.

 

Matsuda T, Matsumoto A, Uchida M, Kanaly RA, Misaki K, Shibutani S, Kawamoto T, Kitagawa K, NakayamaKI, Tomokuni K, Ichiba M. Increased formation of hepatic N2-ethylidene-2'-deoxyguanosineDNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol.Carcinogenesis. 2007 Nov;28(11):2363-6.

  

Matsumoto A, Kawamoto T, Horita M, Takahashi T, Isse T, Oyama T, Ichiba M. Single-doseethanol administration downregulates expression of cytochrome p450 2E1mRNA in aldehyde dehydrogenase 2 knockout mice. Alcohol. 2007 Dec;41(8):587-9.

 

Oyama T, Sugio K, Isse T, Matsumoto A, Nose N, Uramoto H, Nozoe T, Morita M, Kagawa N, Osaki T, Muto M, Yasumoto K, Kawamoto T. Expression of cytochrome P450 in non-small cell lung cancer. Front Biosci. 2008 May 1;13:5787-93. Review.

 

Matsumoto A, Kawamoto T, Mutoh F, Isse T, Oyama T, Kitagawa K, Nakayama KI, Ichiba M. Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice. Pharmacogenet Genomics. 2008 Oct;18(10):847-52.

 

Nagayoshi H, Matsumoto A, Nishi R, Kawamoto T, Ichiba M, Matsuda T. Increased formation of gastricN(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2knockout mice treated with ethanol. Mutat Res. 2009 Feb 19;673(1):74-7.

 

市場正良, 高橋達也,山下善功,高石恵子,西村晃一,蒲池将史, 近藤敏弘,松本明子,上野大介,宮島徹. 佐賀環境フォーラムにおけるシックスクール問題への取り組み. 日本衛生学雑誌 2009 64:26-31

 

Matsumoto A, Ino T, Ohta M, Otani T, Hanada S, Sakuraoka A, Matsumoto A, Ichiba M, Hara M. Enzyme-linked immunosorbent assay of nicotine metabolites. Environ Health Prev Med. 2010 Jul;15(4):211-6.

 

Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V. Evolutionary divergence and functions of the human interleukin (IL) gene family. Hum Genomics. 2010 Oct;5(1):30-55.

 

Chen Y, Orlicky DJ, Matsumoto A, Singh S, Thompson DC, Vasiliou V. Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer. Biochem Biophys Res Commun. 2011 Feb 11;405(2):173-9.

 

Black W, Chen Y, Matsumoto A, Thompson DC, Lassen N, Pappa A, Vasiliou V. Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal. Free Radic Biol Med. 2012 May 1;52(9):1937-44. 

 

Singh S, Brocker C, Koppaka V, Chen Y, Jackson BC, Matsumoto A, Thompson DC, Vasiliou V. Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress. Free Radic Biol Med. 2013 Mar;56:89-101.

 

Matsumoto A, Matsumoto A, Ichiba M, Payton NM, Oishi H, Hara M. Simultaneous measurement of urinary total nicotine and cotinine as biomarkers of active and passive smoking among Japanese individuals. Environ Health Prev Med. 2013 May;18(3):244-50.

 

Matsumoto A, Vasiliou V, Kawamoto T, Tanaka K, Ichiba M. Ethanol reduces lifespan, body weight, and serum alanine aminotransferase level of aldehyde dehydrogenase 2 knockout mouse. Alcohol Clin Exp Res. 2014 Jul;38(7):1883-93.

  

Kwon HJ, Won YS, Park O, Chang B, Duryee MJ, Thiele GE, Matsumoto A, Singh S, Abdelmegeed MA, Song BJ, Kawamoto T, Vasiliou V, Thiele GM, Gao B. Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice. Hepatology. 2014 Jul;60(1):146-57.

 

Jang JH, Bruse S, Liu Y, Duffy V, Zhang C, Oyamada N, Randell S, Matsumoto A, Thompson DC, Lin Y, Vasiliou V, Tesfaigzi Y, Nyunoya T. Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity. Free Radic Biol Med. 2014 Mar;68:80-6.

 

Singh S, Chen Y, Matsumoto A, Orlicky DJ, Dong H, Thompson DC, Vasiliou V. ALDH1B1 links alcohol consumption and diabetes. Biochem Biophys Res Commun. 2015 Aug 7;463(4):768-73.

 

松本明子  血清肝逸脱酵素値における飲酒とALDH2遺伝子多型の交互作用 細胞 47(14) 2015

 

松本明子 アルデヒド脱水素酵素 2(ALDH2)の構造・機能の基礎と ALDH2 遺伝子多型の重要性 日衛誌 71, 55-68 (2016)

 

Matsumoto AThompson DCChen YVasiliou V, Kawamoto T, Ichiba M. Heme oxygenase 1 protects ethanol-administered liver tissue in Aldh2 knockout mice. Alcohol. 52, May 2016, 49–54

 

Chen Y, Singh S, Matsumoto A, Manna SK, Abdelmegeed MA, Golla S, Murphy RC, Dong H, Song BJ, Gonzalez FJ, Thompson DC, Vasiliou V. Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway. Sci Rep. 2016 July; 6:29743.

  

Matsumoto A, Thompson DC, Chen Y, Kitagawa K and Vasiliou V. Roles of defective ALDH2 polymorphism on liver protection and cancer development. Environ Health Prev Med. 2016 Nov;21(6):395-402. Review.

 

Matsumoto A, Shimanoe C, Tanaka K, Ichiba M, Hara M. Development of suitable method for large-scale urinary glucocorticoid analysis by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Apr 21;1057:62-69. doi: 10.1016/j.jchromb.2017.04.031.

 

Matsumoto A, Arcaroli J, Chen Y, Gasparetto M, Neumeister V, Thompson DC, Singh S, Smith C, Messersmith W, Vasiliou V. Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer. Br J Cancer. 2017 Nov 7;117(10):1537-1543.

 

松本明子 アルデヒド脱水素酵素2(ALDH2)遺伝子多型の予防医学的重要性 日衛誌 2018, 73, 9-20

 

 

主要著書

松本明子.酸素.高野健人、伊藤洋子、河原和夫、川本俊弘、城戸照彦、中谷陽二、中山健夫、本橋豊 編.社会医学事典.東京: 朝倉書店、2002; 242-243 

 

川本俊弘,松本明子:ビスフェノールA.荻野景規,小栗一太編:環境化学物質代謝とその周辺.35-44,日本公衆衛生協会.東京 2003

 

松本明子:ビスフェノールAジグリシジルエーテル.荻野景規,小栗一太編:環境化学物質代謝とその周辺.285-292,日本公衆衛生協会.東京 2003